The use of IRAC Group 4 nicotinic acetylcholine receptor agonists (nAChR) has grown considerably since the introduction of the neonicotinoid insecticide imidacloprid, which was commercialized in 1991. The ten insecticides are classified in four sub-groups 4A-4D. The updated guidelines include a table showing the latest resistance status to the neonicotinoid insecticides.