Latest Resistance management for sustainable agriculture and improved public health

The IRAC Mode of Action Classification Online

The definitive, global scheme on the target sites of acaricides and insecticides.

Effective IRM strategies: Sequences or alternations of MoA

Effective insecticide resistance management (IRM) strategies seek to minimise the selection of resistance to any one type of insecticide.  In practice, alternations, sequences or rotations of compounds from different MoA groups provide sustainable and effective IRM.  Applications are often arranged into MoA spray windows or blocks that are defined by the stage of crop development and the biology of the lepidopteran species of concern.  Local expert advice should always be followed with regard to spray windows and timing.  Several sprays may be possible within each spray window, but it is generally essential that successive generations of the pest are not treated with compounds from the same MoA group.  Metabolic resistance mechanisms may give cross-resistance between MoA groups; where this is known to occur, the above advice should be modified accordingly. 

Jump to colour key

Modes of action are colour-coded according to the physiological functions affected. This informs the symptomology, speed of action and other properties of the actives therein and not for any resistance management purpose. Base rotations for resistance management on the mode of action number only.

  • Nerve & Muscle Most current insecticides act on nerve and muscle targets. Insecticides that act on these targets are generally fast acting.
  • Growth Insect development is controlled by juvenile hormone and ecdysone, by directly perturbing cuticle formation/deposition or lipid biosynthesis. Such insect growth regulators are generally slow to moderately slow acting.
  • Respiration Several insecticides are known to interfere with mitochondrial respiration by the inhibition of electron transport and/or oxidative phosphorylation. Such insecticides are generally fast to moderately fast acting.
  • Midgut Lepidopteran-specific microbial toxins that are sprayed or expressed in transgenic crop varieties.
  • Protein Suppressors Multiple biological processes govern the accumulation of proteins critical to supporting a wide variety of functions within insects. Protein suppressors act through reduction of specific protein levels in the pest species. Insecticides that act in this manner are generally moderately slow acting.
  • Unknown or Non-Specific Several insecticides are known to affect less well-described target-sites or functions, or to act non-specifically on multiple targets.

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