Latest Resistance management for sustainable agriculture and improved public health

Nematicides Mode of Action Classification

The definitive, global scheme on the target sites of nematicides.

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Modes of action are colour-coded according to the physiological functions affected. This informs the symptomology, speed of action and other properties of the actives therein and not for any resistance management purpose. Base rotations for resistance management on the mode of action number only.

  • Nerve & Muscle These nematicides may affect the central nervous system of nematodes by inhibiting acetylcholinesterase activity, or glutamate-gated chloride channels that are found in nerve and muscle cells.
  • Growth & Development These nematicides act as lipid biosynthesis inhibitors that reduce lipid content, slowing down nematode development, impacting moulting and reducing fecundity.
  • Respiration These nematicides interfere with mitochondrial respiration by the inhibition of electron transport and/or oxidative phosphorylation. Such nematicides are generally fast acting.
  • Unknown or Non-Specific These nematicides affect less well-described target-sites or functions, or may act non-specifically on multiple targets.

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