In a situation in which running real-world experiments is impractical (or even impossible), computer simulations offer a powerful solution to understand complex problems. This is exactly the case of resistance-evolution prediction: Although fast from an evolutionary perspective, the time and spatial scales involved in this process are simply too large to be dealt with experimentally. The underlying evolutionary processes of resistance development are relatively well known, however. With this knowledge, researchers can build mathematical models to describe and mimic the actual systems. These models can also be calibrated based on real-world cases that have already occurred, improving their precision and accuracy. Read the full paper